Name: Drury Inn & Suites Sikeston, MO
Price range: $103 total
Rating: 9.4

Your Mississippi County Vacation

Book a vacation package to Mississippi County and make planning your adventure easy. With all the logistics arranged before you depart, you can focus on enjoying every minute in this exciting destination. A trip to Mississippi County promises plenty to see and do. Not sure where to start? Charleston is one of the most popular cities to stay here. Stop dreaming and start packing, because your Mississippi County vacation is only clicks away with Expedia.

The Latest Mississippi County Vacation Packages

Price found within the past 48 hours. Click for updated prices.

Quality Inn Cairo I-57

$1,271

per person

Feb 2 - Feb 4

found 24 hours ago

Roundtrip flight included

San Francisco (SFO) to Paducah (PAH)

6.6/10 (272 reviews)

Break fast was excellent

Reviewed on Sep 28, 2025

Hampton Inn & Suites Paducah

$1,356

per person

Feb 2 - Feb 4

found 24 hours ago

Roundtrip flight included

San Francisco (SFO) to Paducah (PAH)

9.2/10 Wonderful! (562 reviews)

Great staff, clean room and quiet

Reviewed on Nov 22, 2025

Comfort Suites

$1,298

per person

Feb 2 - Feb 4

found 24 hours ago

Roundtrip flight included

San Francisco (SFO) to Paducah (PAH)

8.6/10 Excellent! (900 reviews)

The check in was ok. Room was comfortable, but the bathroom needs much upgrade. Shampoo bottles etc. would not stay hooked to the wall and the bottle fell and spilled on the shower floor making it VERY slippery and I slipped and almost fell. There was MOLD around the whole bottom of the shower floor. Short on 2 towels.

Reviewed on Dec 1, 2025

The Respite Bed and Breakfast

$1,335

per person

Feb 2 - Feb 4

found 24 hours ago

Roundtrip flight included

San Francisco (SFO) to Paducah (PAH)

9.8/10 Exceptional! (270 reviews)

This was a return visit for us. It's a quick trip from our home to get away here and we love it. It's always clean and the folks are friendly. Love the breakfast vouchers too.

Reviewed on Nov 29, 2025

Harrah's Metropolis Hotel & Casino - A Caesars Rewards Destination

$1,282

per person

Feb 2 - Feb 4

found 24 hours ago

Roundtrip flight included

San Francisco (SFO) to Paducah (PAH)

8.2/10 Very Good! (1,000 reviews)

Other than loosing my money it was a nice stay👍

Reviewed on Nov 11, 2025

Find the Best Mississippi County Vacation Packages

Mississippi County Essential Information

Language	English
Currency	U.S dollars
Closest Airport	Nashville Intl. Airport (BNA)

Mississippi County Hotel Deals

Super 8 by Wyndham Charleston/Sikeston East MO

310 S Story St Charleston MO

Fully refundableReserve now, pay when you stay

$69 nightly

$77 total

Dec 7 - Dec 8

Total with taxes and fees

6.6/10 (610 reviews)

Thank you

Reviewed on Nov 7, 2025

Quality Inn Charleston - Sikeston

102 Drake St Charleston MO

Fully refundableReserve now, pay when you stay

$65 nightly

$72 total

Dec 27 - Dec 28

Total with taxes and fees

6.8/10 (406 reviews)

Ladydi

The only issue was the temperature display on the ac/heating unit went to E5 during the night and it was overly warm. I woke up because of this and was able to get the fan only running but it was still uncomfortable for me and I spent 5 hours tossing and turning with little sleep after that with ...

Reviewed on Oct 22, 2025

Drury Inn & Suites Sikeston, MO

2608 East Malone Ave, Miner Sikeston MO

Fully refundableReserve now, pay when you stay

$90 nightly

$103 total

Dec 10 - Dec 11

Total with taxes and fees

9.4/10 Exceptional! (1,000 reviews)

Clean big room, great staff

Reviewed on Nov 30, 2025

See all 98 properties in Mississippi County

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.