A bridge over a muddy river with green trees and hills in the background.

Mississippi County Vacations & Trips from $484

Book a Hotel + Flight or Car together to unlock savings

Your Mississippi County Vacation

Book a vacation package to Mississippi County and make planning your adventure easy. With all the logistics arranged before you depart, you can focus on enjoying every minute in this exciting destination. A trip to Mississippi County promises plenty to see and do. Not sure where to start? Charleston is one of the most popular cities to stay here. Stop dreaming and start packing, because your Mississippi County vacation is only clicks away with Expedia.

Top destinations in Mississippi County

A sunset over a calm lake with tall trees reflected in the water.
FlightsHotels

Charleston

Charleston

The Latest Mississippi County Vacation Packages

Price found within the past 48 hours. Click for updated prices.
  • A hotel room with a large bed, a desk, a TV, and a dresser.
    Dec 28 - Dec 30

    Red Roof Inn Cadiz + Flight

    Cadiz
    2 nights
    2.0 star property
    8.4/10 - Very good (486 reviews)
    Roundtrip • Dallas (DFW) - Paducah (PAH)
    DFW - PAH • 1 stop PAH - DFW • 1 stop
    $496
    $484
    per traveler
    found 16 hours ago
    Red Roof Inn Cadiz
  • A modern lobby with a reception desk, seating area, and large windows.
    Dec 28 - Dec 30

    La Quinta Inn & Suites by Wyndham Hopkinsville + Flight

    Hopkinsville
    2 nights
    3.0 star property
    7.6/10 - Good (1,002 reviews)
    Roundtrip • Dallas (DFW) - Paducah (PAH)
    DFW - PAH • 1 stop PAH - DFW • 1 stop
    $505
    $492
    per traveler
    found 16 hours ago
    La Quinta Inn & Suites by Wyndham Hopkinsville
  • A reception desk with a black and wooden design, a framed artwork, a mirror, and a sign for Lakehouse Inn.
    Dec 28 - Dec 30

    The Lakehouse Inn at Sledd Creek + Flight

    Gilbertsville
    2 nights
    2.0 star property
    10/10 - Exceptional (192 reviews)
    "We were so presently surprised how wonderful this property was! Beautifully decorated, close to Patti's 1800 Settlement, clean beyond clean room, breakfast too - and the espresso iced coffees were made for us! Highly recommend!!"
    Reviewed November 8, 2026
    Roundtrip • Dallas (DFW) - Paducah (PAH)
    DFW - PAH • 1 stop PAH - DFW • 1 stop
    $602
    $587
    per traveler
    found 16 hours ago
    The Lakehouse Inn at Sledd Creek
  • A spacious lobby with a fireplace, comfortable seating, and a large TV screen.
    Dec 28 - Dec 30

    Comfort Suites Hopkinsville near Fort Campbell + Flight

    Hopkinsville
    2 nights
    2.5 star property
    8.8/10 - Excellent (641 reviews)
    Roundtrip • Dallas (DFW) - Paducah (PAH)
    DFW - PAH • 1 stop PAH - DFW • 1 stop
    $519
    $506
    per traveler
    found 16 hours ago
    Comfort Suites Hopkinsville near Fort Campbell
  • A wooden porch with white rocking chairs, a covered seating area, and a sign for a tailor shop.
    Dec 28 - Dec 30

    The Outpost + Flight

    Grand Rivers
    2 nights
    2.0 star property
    9.2/10 - Wonderful (37 reviews)
    Roundtrip • Dallas (DFW) - Paducah (PAH)
    DFW - PAH • 1 stop PAH - DFW • 1 stop
    $548
    $535
    per traveler
    found 16 hours ago
    The Outpost

Discover the most popular places to visit in Mississippi County

Big Oak Tree State Park

8.0/10 (20 reviews)
You can take time to visit Big Oak Tree State Park during your travels to East Prairie. While you're in the area, wander around the parks.
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Mississippi County Hotel Deals

A building with a fountain and flower beds in front.

The Riverstone Hotel Charleston-Sikeston

The Riverstone Hotel Charleston-Sikeston
2.5 star property
6.4 mi from Mississippi County
6.8 out of 10, (443 reviews)
$66 nightly
The price is $74
Nov 13 - Nov 14
Total with taxes and fees
The Riverstone Hotel Charleston-Sikeston
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
See all properties in Mississippi County
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.