Name: Drury Inn & Suites Sikeston, MO
Price range: $108 total
Rating: 9.4

Your Mississippi County Vacation

Book a vacation package to Mississippi County and make planning your adventure easy. With all the logistics arranged before you depart, you can focus on enjoying every minute in this exciting destination. A trip to Mississippi County promises plenty to see and do. Not sure where to start? Charleston is one of the most popular cities to stay here. Stop dreaming and start packing, because your Mississippi County vacation is only clicks away with Expedia.

Top destinations in Mississippi County

Cypress Trees on the Horizon. A sting of cypress trees of various sizes extend across the horizon as the sunken sun paints the multicolored sky.

The Mississippi River near Hannibal, Missouri, USA

The Latest Mississippi County Vacation Packages

Price found within the past 48 hours. Click for updated prices.

University Inn of Carbondale

$615

per person

May 11 - May 18

found 11 hours ago

Roundtrip non-stop flight included

New York (NYC) to Cape Girardeau (CGI)

6/10 (349 reviews)

The room was alright, it needed cleaned a litter better..... The staff on the kiosk, was nice, however, the woman was not very kind at all

Reviewed on Jan 22, 2026

Hampton Inn Carbondale

$837

per person

May 11 - May 18

found 11 hours ago

Roundtrip non-stop flight included

New York (NYC) to Cape Girardeau (CGI)

8.4/10 Very Good! (625 reviews)

I’m upset because I booked this hotel for the pool specifically and it was under maintenance which id only found out after checking in. I didn’t stay there for the rest of the night, but I was clean.

Reviewed on Mar 23, 2026

Holiday Inn Carbondale-Conference Center by IHG

$897

per person

May 11 - May 18

found 11 hours ago

Roundtrip non-stop flight included

New York (NYC) to Cape Girardeau (CGI)

8.8/10 Excellent! (660 reviews)

Clean and well taken care of. Breakfast was amazing. Staff was on top of everything!

Reviewed on Mar 9, 2026

Home2 Suites by Hilton Carbondale

$1,087

per person

May 11 - May 18

found 11 hours ago

Roundtrip non-stop flight included

New York (NYC) to Cape Girardeau (CGI)

8.8/10 Excellent! (529 reviews)

Yes. Not a lot of shopping nearby

Reviewed on Mar 14, 2026

Quality Inn Carbondale University area

$648

per person

May 11 - May 18

found 11 hours ago

Roundtrip non-stop flight included

New York (NYC) to Cape Girardeau (CGI)

5.8/10 (840 reviews)

I’ve used quality inn before, and always been happy with my stay. The room I had at this location was not nearly as clean, it was pretty disappointing.

Reviewed on Mar 27, 2026

Find the Best Mississippi County Vacation Packages

Mississippi County Essential Information

Language	English
Currency	U.S dollars
Closest Airport	Nashville Intl. Airport (BNA)

Mississippi County Hotel Deals

The Riverstone Hotel Charleston-Sikeston

102 Drake St Charleston MO

Fully refundableReserve now, pay when you stay

$58 nightly

$64 total

Mar 29 - Mar 30

Total with taxes and fees

Super 8 by Wyndham Charleston/Sikeston East MO

310 S Story St Charleston MO

Fully refundableReserve now, pay when you stay

$62 nightly

$69 total

Mar 29 - Mar 30

Total with taxes and fees

6.8/10 (627 reviews)

Mold on ceiling, pillows were absolutely filthy, dust everywhere, dirt getting stuck to feet on floors, Breakfast was nutra grain bars, cereal, and apples, terrible selection no hot food whatsoever. I do not recommend

Reviewed on Mar 27, 2026

Drury Inn & Suites Sikeston, MO

2608 East Malone Ave, Miner Sikeston MO

Fully refundableReserve now, pay when you stay

$94 nightly

$108 total

Apr 5 - Apr 6

Total with taxes and fees

9.4/10 Exceptional! (1,001 reviews)

Bedding needs to be updated. Pillows smelled and carpet could be cleaned. Bathroom was clean. Staff was friendly and helpful.

Reviewed on Mar 24, 2026

See all 105 properties in Mississippi County

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.