Mississippi County Vacation Packages 2026 from $502

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Your Mississippi County Vacation

Book a vacation package to Mississippi County and make planning your adventure easy. With all the logistics arranged before you depart, you can focus on enjoying every minute in this exciting destination. A trip to Mississippi County promises plenty to see and do. Not sure where to start? Charleston is one of the most popular cities to stay here. Stop dreaming and start packing, because your Mississippi County vacation is only clicks away with Expedia.

Top destinations in Mississippi County

A sunset over a calm lake with tall trees reflected in the water.

A tree-lined landscape with a river and fields.

The Latest Mississippi County Vacation Packages

Price found within the past 48 hours. Click for updated prices.

Early American Motel

$502

per person

Oct 22 - Oct 26

found 21 hours ago

Roundtrip non-stop flight included

New York (NYC) to Paducah (PAH)

9/10 Wonderful! (312 reviews)

Check in at 1:00 am. Front desk staff was very helpful

Reviewed on Aug 31, 2026

EC Reed's Mercantile and Hotel

$792

per person

Nov 18 - Nov 24

found 1 day ago

Roundtrip non-stop flight included

Newark Liberty Intl. Airport (EWR) to Cape Girardeau (CGI)

9.4/10 Exceptional! (109 reviews)

Always enjoy staying here. Clean rooms, comfortable beds and a quiet stay! Breakfast is great along with the shopping out front, free coffee and fruit at the check-in counter! Hometown hospitality! Love it!

Reviewed on Sep 8, 2026

Hampton Inn Oak Grove Fort Campbell

$585

per person

Oct 22 - Oct 26

found 21 hours ago

Roundtrip non-stop flight included

New York (NYC) to Paducah (PAH)

9.4/10 Exceptional! (1,002 reviews)

Breakfast clean room parking staff

Reviewed on Sep 6, 2026

Comfort Suites Paducah Mall Area

$642

per person

Oct 24 - Oct 29

found 1 day ago

Roundtrip non-stop flight included

Phoenix (PHX) to Paducah (PAH)

8.4/10 Very Good! (1,033 reviews)

Nice property, very clean Air conditioner in room was older and extremely loud

Reviewed on Sep 8, 2026

Harrah's Metropolis Hotel & Casino - A Caesars Rewards Destination

$608

per person

Oct 24 - Oct 29

found 1 day ago

Roundtrip non-stop flight included

Phoenix (PHX) to Paducah (PAH)

8.2/10 Very Good! (1,003 reviews)

Excellent hotel with a casino attached. The front desk clerk recommended two nearby restaurants. We tried the Italian restaurant, and it was excellent.

Reviewed on Aug 30, 2026

Find the Best Mississippi County Vacation Packages

Mississippi County Essential Information

Language	English
Currency	U.S dollars
Closest Airport	Nashville Intl. Airport (BNA)

Mississippi County Hotel Deals

Super 8 by Wyndham Charleston/Sikeston East MO

310 S Story St Charleston MO

Fully refundableReserve now, pay when you stay

$60 nightly

$66 total

Sep 10 - Sep 11

Total with taxes and fees

The Riverstone Hotel Charleston-Sikeston

102 Drake St Charleston MO

Fully refundable

$66 nightly

$73 total

Sep 19 - Sep 20

Total with taxes and fees

6.8/10 (431 reviews)

"Everything was fine for a one night stay."

Reviewed on Sep 7, 2026

Drury Inn & Suites Sikeston, MO

2608 East Malone Ave, Miner Sikeston MO

Fully refundableReserve now, pay when you stay

$94 nightly

$108 total

Sep 13 - Sep 14

Total with taxes and fees

9.6/10 Exceptional! (1,007 reviews)

"This was my second time staying at Drury hotel. I will most definitely book another stay."

Reviewed on Sep 6, 2026

See all 112 properties in Mississippi County

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.