Mississippi County Vacations & Trips from $496
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Your Mississippi County Vacation
Book a vacation package to Mississippi County and make planning your adventure easy. With all the logistics arranged before you depart, you can focus on enjoying every minute in this exciting destination. A trip to Mississippi County promises plenty to see and do. Not sure where to start? Charleston is one of the most popular cities to stay here. Stop dreaming and start packing, because your Mississippi County vacation is only clicks away with Expedia.
Top destinations in Mississippi County
Charleston
East Prairie
The Latest Mississippi County Vacation Packages
Price found within the past 48 hours. Click for updated prices.
Rockwood Inn
Price was $593, price is now $533 per person
$533
per person
Jul 26 - Jul 28
found 1 day ago
Roundtrip flight included
Dallas (DFW) to Cape Girardeau (CGI)
10/10 Exceptional! (20 reviews)
My stay was cozy, warm and inviting, and absolutely wonderful shower. I will definitely be returning!
Reviewed on Dec 28, 2025
Drury Plaza Hotel Cape Girardeau Conference Center
Price was $522, price is now $505 per person
$505
per person
Jul 26 - Jul 28
found 1 day ago
Roundtrip flight included
Dallas (DFW) to Cape Girardeau (CGI)
9.6/10 Exceptional! (1,006 reviews)
It was my first time staying at the Drury hotel and I have no complaints. Room was perfect, bed very comfortable, plus they had a happy hour with a couple of free drinks and appetizers! The next morning free hot breakfast! Really enjoyed our stay and will definitely stay again!!
Reviewed on Jun 1, 2026
Drury Inn & Suites Cape Girardeau
Price was $524, price is now $509 per person
$509
per person
Jul 26 - Jul 28
found 1 day ago
Roundtrip flight included
Dallas (DFW) to Cape Girardeau (CGI)
9.4/10 Exceptional! (1,004 reviews)
Breakfast was not a typical hotel breakfast, it was more like a restaurant . Lot of options and very good food.
Bed and pillows were very comfy.
First time staying at Drury but, now we will definitely will stay again anytime we can.
Reviewed on Jun 1, 2026
The Riverview
Price was $547, price is now $533 per person
$533
per person
Jul 26 - Jul 28
found 1 day ago
Roundtrip flight included
Dallas (DFW) to Cape Girardeau (CGI)
9.4/10 Exceptional! (580 reviews)
Out room wasn't ready (we arrived a little after 3, check-in time). We had to wait for the room to be cleaned. Other than that, it was clean and comfortable. I wish they had a better breakfast option and an earlier time.
Reviewed on Jun 1, 2026
Find the Best Mississippi County Vacation Packages
Mississippi County Essential Information
Language | English |
|---|---|
Currency | U.S dollars |
Closest Airport | Nashville Intl. Airport (BNA) |
Mississippi County Hotel Deals
Super 8 by Wyndham Charleston/Sikeston East MO
310 S Story St Charleston MO
Fully refundableReserve now, pay when you stay
$60 nightly
The price is $66 total per night from Jun 7 to Jun 8
$66 total
Jun 7 - Jun 8
Total with taxes and fees
6.6/10 (637 reviews)
"Clean rooms,"
Reviewed on May 31, 2026
The Riverstone Hotel Charleston-Sikeston
102 Drake St Charleston MO
Fully refundableReserve now, pay when you stay
$75 nightly
The price is $83 total per night from Jun 3 to Jun 4
$83 total
Jun 3 - Jun 4
Total with taxes and fees
6.8/10 (413 reviews)
"They cha rged me twice. They promised a refund but I have not seen it yet. Windows was taped up so I could not see out. Room smelled bad. I was also unhappy with the Expedia app."
Reviewed on Jun 1, 2026
Drury Inn & Suites Sikeston, MO
2608 East Malone Ave, Miner Sikeston MO
Fully refundableReserve now, pay when you stay
$111 nightly
The price is $128 total per night from Jun 7 to Jun 8
$128 total
Jun 7 - Jun 8
Total with taxes and fees
9.6/10 Exceptional! (1,005 reviews)
"The ladies at the desk and in the dinner area were great!"
Reviewed on May 31, 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.
